Location: Home > Professor
Li Cui
Highest Education:
1799 Jimei Road, Xiamen
Zip Code:

Education and Appointments:


1998-2002: BSc, Xiamen University, Xiamen, P. R. China
2002-2008: PhD, Xiamen University, Xiamen, P. R. China
2007: visiting student, Southampton University, Southampton, UK.


2019.01-Present: Professor, Institute of Urban Environment, CAS
2010.09-2018.12: Associate Professor, Institute of Urban Environment, CAS
2008.09-2010.09: Assistant Professor, Institute of Urban Environment, CAS
2015.08- 2016.02: Visiting scholar, Oxford University, UK
2015.02- 2015.07: Visiting scholar, Lancaster University, UK
2009.11- 2010.02: Visiting scholar, Bern University, Switzerland

Main academic contributions:
Research Interest:

Her research interest is developing single-cell Raman/surface-enhanced Raman spectroscopy coupled with stable isotope probing, single-cell sorting and sequencing for investigating environmental and clinical microorganisms, including antibiotic resistant bacteria, functional bacteria driving N and P biogeochemical cycling, biofilms (biofouling), microplastics, nanotoxicity. Dr. Cui has coauthored more than 40 papers published in J. Am. Chem. Soc., Nat Proto, Anal. Chem., Environ. Sci. Technol, Water Res J. Phys. Chem. C et al.

Selected Publications:

1. Cui, L., Liu, B., Vonlanthen, D., Mayor, M., Fu, Y.C., Li, J.F. and Wandlowski, T.*, In Situ Gap-Mode Raman Spectroscopy on Single-Crystal Au(100) Electrodes: Tuning the Torsion Angle of 4,4 '-Biphenyldithiols by an Electrochemical Gate Field. J. Am. Chem. Soc. 2011, 133(19), 7332-7335.
2. Yang, K.; Li, H. Z.; Zhu, X.; Su, J. Q.; Ren, B.; Zhu, Y. G.; Cui, L*., Rapid Antibiotic Susceptibility Testing of Pathogenic Bacteria Using Heavy-Water-Labeled Single-Cell Raman Spectroscopy in Clinical Samples. Anal. Chem. 2019, 91, 6296-6303.
3. Li, H.-Z.; Bi, Q.-f.; Yang, K.; Zheng, B.-X.; Pu, Q.; Cui, L*., D2O-Isotope-Labeling Approach to Probing Phosphate-Solubilizing Bacteria in Complex Soil Communities by Single-Cell Raman Spectroscopy. Anal. Chem. 2019, 91, (33), 2239-2246.
4. Chen, Q. L.; Zhu, D.; An, X. L.; Ding, J.; Zhu, Y. G.; Cui, L.*, Does nano silver promote the selection of antibiotic resistance genes in soil and plant? Environ Int 2019, 128, 399-406.
5. Morais, C. L. M.; Paraskevaidi, M.; Cui, L.; Fullwood, N. J.; Isabelle, M.; Lima, K. M. G.; Martin-Hirsch, P. L.; Sreedhar, H.; Trevisan, J.; Walsh, M. J.; Zhang, D.; Zhu, Y. G.; Martin, F. L., Standardization of complex biologically derived spectrochemical datasets. Nat Protoc 2019, 14, (5), 1546-1577.
6. Cui, L.; Yang, K.; Li, H.-Z.; Zhang, H.; Su, J.-Q.; Paraskevaidi, M.; Martin, F. L.; Ren, B.; Zhu, Y.-G.*, A novel functional single-cell approach to probing nitrogen-fixing bacteria in soil communities by resonance Raman spectroscopy with 15N2 labelling. Anal. Chem. 2018, 90, 5082-5089.
7. Cui, L*.; Yang, K.; Zhou, G.; Huang, W. E*; Zhu, Y. G., Surface-enhanced Raman spectroscopy combined with stable isotope probing to monitor nitrogen assimilation at both bulk and single-cell level. Anal. Chem. 2017, 89, (11), 5793-5800.
8. Cui, L.; Zhang, Y.-J.; Huang, W. E.; Zhang, B.-F. M., Francis L; Li, J.-Y.; Zhang, K.-S.; Zhu, Y.-G.*, Surface-Enhanced Raman Spectroscopy for Identification of Heavy Metal Arsenic(V)-Mediated Enhancing Effect on Antibiotic Resistance. Anal. Chem. 2016, 88, (6), 3164–3170.
9. Cui, L.*, Chen, P., Chen, S., Yuan, Z., Yu, C., Ren, B. and Zhang, K.*,. In Situ Study of the Antibacterial Activity and Mechanism of Action of Silver Nanoparticles by Surface-Enhanced Raman Spectroscopy. Anal. Chem. 2013, 85(11), 5436-5443.
10. Cui, L., Yao, M., Ren, B. and Zhang, K.-S.*, Sensitive and Versatile Detection of the Fouling Process and Fouling Propensity of Proteins on Polyvinylidene Fluoride Membranes via Surface-Enhanced Raman Spectroscopy. Anal. Chem.2011, 83(5), 1709-1716.
11. Cui, L.*; Chen, P.; Zhang, B.; Zhang, D.; Li, J.; Martin, F. L.; Zhang, K.*, Interrogating chemical variation via layer-by-layer SERS during biofouling and cleaning of nanofiltration membranes with further investigations into cleaning efficiency. Water Res. 2015, 87, 282-291.
12. Chen, Q. L.; An, X. L.; Zhu, Y. G.; Su, J. Q.; Gillings, M. R.; Ye, Z. L.; Cui, L.*, Application of Struvite Alters the Antibiotic Resistome in Soil, Rhizosphere, and Phyllosphere. Environ. Sci. Technol. 2017, 51, (14), 8149-8157.
13. Song, Y.#; Cui, L.#; Lopez, J. A. S.; Xu, J.; Zhu, Y. G.; Thompson, I. P.; Huang, W. E*., Raman-Deuterium Isotope Probing for in-situ identification of antimicrobial resistant bacteria in Thames River. Sci Rep 2017, 7, (1), 16648
14. Chen, Q.-L.; Fan, X.-T.; Zhu, D.; An, X.-L.; Su, J.-Q.; Cui, L*., Effect of biochar amendment on the alleviation of antibiotic resistance in soil and phyllosphere of Brassica chinensis L. Soil Biol. Biochem. 2018, 119, 74-82.
15. Chen, Q. L.; An, X. L.; Li, H.; Zhu, Y. G.; Su, J. Q.; Cui, L.*, Do manure-borne or indigenous soil microorganisms influence the spread of antibiotic resistance genes in manured soil? Soil Biol. Biochem. 2017, 114, 229-237.
16. Chen, P. Y.; Cui, L.*; Zhang, K. S.*, Surface-enhanced Raman spectroscopy monitoring the development of dual-species biofouling on membrane surfaces. J. Membr. Sci. 2015, 473, 36–44.
17. K?gler, M.*; Zhang, B. F.; Cui, L.*; Shi, Y. J.; Yliperttula, M.; Laaksonen, T.; Viitala, T.; Zhang, K., Real-time Raman based approach for identification of biofouling. Sensors and Actuators B: Chemical 2016, 230, 411-421.
18. Zhang, B.; Cui, L.*; Zhang, K.*, Dosage- and time-dependent antibacterial effect of zinc oxide nanoparticles determined by a highly uniform SERS negating undesired spectral variation. Anal Bioanal Chem 2016, 408, (14), 3853-65.
19. Cui, L.*; Butler, H. J.; Martin-Hirsch, P. L.; Martin, F. L.*, Aluminium foil as a potential substrate for ATR-FTIR, transflection FTIR or Raman spectrochemical analysis of biological specimens. Anal Methods-Uk 2016, 8, 481-487.
20. Wang, Y.; Huang, W. E.; Cui, L.; Wagner, M., Single cell stable isotope probing in microbiology using Raman microspectroscopy. Curr. Opin. Biotechnol. 2016, 41, 34-42.
21. Cui, L.*, Chen, S.D. and Zhang, K.S.*, 2015. Effect of toxicity of Ag nanoparticles on SERS spectral variance of bacteria. Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. 137(0), 1061-1066.
22. Cui, L., Wu, D.Y., Wang, A., Ren, B*. and Tian, Z.Q., 2010. Charge-Transfer Enhancement Involved in the SERS of Adenine on Rh and Pd Demonstrated by Ultraviolet to Visible Laser Excitation. J. Phys. Chem. C 114(39), 16588-16595.
23. Cui, L., Ren, B.* and Tian, Z.Q., 2010. Surface-Enhanced Raman Spectroscopic Study on the Co-adsorption of DNA Bases with Perchlorate. Acta Physico-Chimica Sinica 26(2), 397-402.
24. Cui, L., Mahajan, S., Cole, R.M., Soares, B., Bartlett, P.N., Baumberg, J.J., Hayward, I.P., Ren, B., Russell, A.E*. and Tian, Z.Q., 2009. UV SERS at well ordered Pd sphere segment void (SSV) nanostructures. Phys. Chem. Chem. Phys. 11(7), 1023-1026.
25. Cui, L., Wang, A., Wu, D.Y., Ren, B*. and Tian, Z.Q*., 2008. Shaping and Shelling Pt and Pd Nanoparticles for Ultraviolet Laser Excited Surface-Enhanced Raman Scattering. J. Phys. Chem. C 112(45), 17618-17624.
26. Cui, L., Liu, Z., Duan, S., Wu, D.Y., Ren, B*., Tian, Z.Q. and Zou, S.Z., 2005. Orientation change of adsorbed pyrazine on roughened rhodium electrodes as probed by surface-enhanced Raman spectroscopy. J Phys Chem B 109(37), 17597-17602.

Supported Projects:

1. Single-cell Raman and heavy water labelling identify environmental antibiotic resistant bacteria and reveal evolution of antibiotic resistance. National Science Foundation of China (Grants 21777154) (2018.1-2021.12)
2. In situ surface-enhanced Raman scattering (SERS) study of biofilm on membrane surface: formation process and influencing factors. National Science Foundation of China (Grants 21173208) (2012.1-2015.12)
3. Developing surface-enhanced Raman spectroscopy for in situ study of the membrane fouling mechanism in a membrane bioreactor. National Science Foundation of China (Grants 20903076) (2010.1-2012.12). Finished.
4. SERS study of antibacterial mechanism of graphene and carbon nanotubes. National Science Foundation of Ningbo (Grants 2014A610107)(2014.4.1-2016.3.31)
5. In-situ SERS study of toxic effect of carbon nanomaterials on biofilm. National Science Foundation of Fujian province (Grants 2015J01067) (2015. 4-2018. 4)