Porous GdAlO3: Cr3+, Sm3+ drug carrier for real-time long afterglow and magnetic resonance dual-mode imaging |
Li, JL (Li, Jinlei); Wang, CC (Wang, Chengcheng); Shi, JP (Shi, Junpeng); Li, PH (Li, Penghui); Yu, ZF (Yu, Zhenfeng); Zhang, HW* (Zhang, Hongwu) |
Here, a kind of porous nanoparticles GdAlO3:Cr3+, Sm3+ (GAO:Cr,Sm) which own magnetic resonance and long persistent luminescent properties have been synthesized. The spherical morphology and narrow size distribution would allow the GAO:Cr,Sm nanoparticles to be utilised as a drug carrier and the drug release results indicate that the GAO:Cr,Sm drug carriers have an excellent drug sustained properties. Applying the Cr3+ and Sm3+ coped with gadolinium aluminate as the NIR persistent luminescence center and the energy transfer resonance from Gd3+ to Cr3+, these nanoparticles exhibit excellent NIR persistent luminescence at 732 nm under the UV irradiation of 254 nm and it can persist for about half an hour. In addition, they possess a longitudinal relaxivity (r1) value of 4.75 mM-1 s-1, which means that these nanoparticles could be applied for MR imaging as contrast agents. Carboxymethyl Chitosan was modified on the surface of GAO:Cr,Sm nanoparticles to make them owning excellent biocompatibility and low toxicity and these nanoparticles were successful to realize in vivo imaging. Hence, the well-defined nanoprobes of GAO:Cr,Sm exhibit great potential in biomedicine as trackable drug carriers and in vivo imaging agent due to the dual-model imaging property. |
Key words:Drug carrier; Long afterglow imaging; Magnetic resonance imaging; Porous nanoparticles |
Volume:199 Page:363-371 Journal:JOURNAL OF LUMINESCENCE |
https://doi.org/10.1016/j.watres.2018.09.011
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